ALKBH4

Across TCGA cell cohorts, ALKBH4 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ALKBH4-associated genes across cancer lineages are MSGN1, EN1, and TMCO5A. Each is linked with ALKBH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALKBH4-to-partner and partner-to-ALKBH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by ALKBH4-low versus ALKBH4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH4→partner) and Y-score (partner→ALKBH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.083	+3.023	<.001	.002	3	1
LARGE_INTESTINE	EN1 →	+1.288	+3.536	<.001	.003	3	1
LARGE_INTESTINE	TMCO5A →	+0.013	+3.415	<.001	.001	3	1
LARGE_INTESTINE	CYYR1 →	+0.021	+3.256	<.001	.005	3	1
LARGE_INTESTINE	GPX4 →	+0.653	+3.064	<.001	.009	3	1
LARGE_INTESTINE	C10orf53 →	+0.011	+3.310	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

MSGN1 by ALKBH4 expression — LARGE_INTESTINE

Explore this box plot interactively →