ALKBH3

Across TCGA patient cohorts, ALKBH3 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALKBH3-associated genes across cancer lineages are mTOR_pS2448, EGFR_pY1068, and A-Raf_pS299. Each is linked with ALKBH3 in more than 3 cancer types. Because this analysis shows association rather than direction, both ALKBH3-to-partner and partner-to-ALKBH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ALKBH3-low versus ALKBH3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH3→partner) and Y-score (partner→ALKBH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.098	-1.342	.028	.034	3	4
UCEC	EGFR_pY1068 →	-0.208	-1.807	.005	.003	3	2
UCEC	A-Raf_pS299 →	-0.073	-1.765	.041	.013	3	2
UCEC	JNK_pT183_Y185 →	-0.140	-1.736	.005	.006	3	2
COAD	PCNA →	+0.351	+3.008	.006	.019	3	2
COAD	PRDX1 →	+0.295	+3.025	<.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

mTOR_pS2448 by ALKBH3 expression — UCEC

Explore this box plot interactively →