ALKBH3

Across TCGA pan-cancer cohorts, ALKBH3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ALKBH3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ALKBH3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ALKBH3 is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where ALKBH3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALKBH3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.603	<.001	8	view →
COAD	Male	II,III,IV	+0.412	<.001	8	view →
KIRC	All	All	+0.292	<.001	7	view →
UCEC	All	All	−1.437	<.001	6	view →
BRCA	Female	II,III,IV	−0.391	<.001	4	view →
THCA	Male	III,IV	−0.279	.004	4	view →
LIHC	Male	All	+0.510	<.001	3	view →
CHOL	All	All	+0.923	.039	2	view →
KICH	All	All	−0.334	.013	2	view →
LUAD	Male	All	−0.306	.005	2	view →
LUSC	Male	All	+0.257	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ALKBH3–HNSC

Open the HNSC breakdown →