ALKBH3

Across TCGA pan-cancer cohorts, ALKBH3 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated ALKBH3 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher ALKBH3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ALKBH3 expression acts as an unfavorable survival marker, although some lineages such as KIRC and CHOL show a favorable association.

KICH, BLCA, and ACC are the cancer types where ALKBH3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	All	0.730	1.000	<.001	104	view →
BLCA	OS	Quartile	All	0.369	0.554	.008	27	view →
ACC	DFS	Quartile	II,III,IV	0.194	0.723	.003	22	view →
KIRC	DFS	Tertile	III,IV	0.763	0.495	.009	20	view →
KIRP	DFS	Median	II,III,IV	0.332	0.636	.033	17	view →
CHOL	DFS	Median	IV	0.858	0.339	.017	15	view →
GBM	OS	Tertile	All	0.290	0.539	.010	12	view →
UCEC	OS	Quartile	IV	0.723	0.235	.004	12	view →
OV	OS	Median	All	0.803	0.876	.010	12	view →
LUSC	DFS	Quartile	III,IV	0.517	0.823	.001	11	view →
HNSC	DFS	Median	III,IV	0.637	0.719	.027	10	view →
LIHC	DFS	Median	All	0.182	0.377	.012	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

ALKBH3–KICH (OS)

Open the KICH breakdown →