ALKBH3

Across TCGA cell cohorts, ALKBH3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,540 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ALKBH3-associated GO terms across cancer lineages are Endoplasmic reticulum to Golgi vesicle-mediated transport, Protein histidyl modification to diphthamide, and Peptidyl-histidine modification. Each is linked with ALKBH3 in more than 5 cancer types. Because this analysis shows association rather than direction, both ALKBH3-to-partner and partner-to-ALKBH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum to Golgi vesicle-mediated transport grouped by ALKBH3-low versus ALKBH3-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALKBH3→partner) and Y-score (partner→ALKBH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.050	+0.752	<.001	.004	3	6
LUNG_NSCLC_LUSC	Protein histidyl modification to diphthamide →	+0.104	+0.789	<.001	.001	3	6
LUNG_NSCLC_LUSC	Peptidyl-histidine modification →	+0.104	+0.789	<.001	.001	3	6
UPPER_AERODIGESTIVE_TRACT	Protein transmembrane transport →	+0.045	+0.442	.001	.001	3	6
LIVER	Positive regulation of establishment of T cell polarity →	+0.203	+1.462	<.001	.002	3	5
SOFT_TISSUE	Protein targeting to ER →	+0.071	+0.692	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,540 associations by consensus.

Endoplasmic reticulum to Golgi vesicle-mediated transport by ALKBH3 expression — BLOOD_Leukemia

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