ALG14

Across TCGA patient cohorts, ALG14 mutation is significantly associated with the RNA expression of many other genes, with 143 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ALG14-associated genes across cancer lineages are RWDD1, RN7SL134P, and RNU6-548P. Each is linked with ALG14 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALG14-to-partner and partner-to-ALG14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RWDD1 grouped by ALG14-low versus ALG14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG14→partner) and Y-score (partner→ALG14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RWDD1 →	+0.703	+3.255	<.001	.009	3	2
UCEC	RN7SL134P →	+0.225	+3.014	<.001	.004	3	2
UCEC	RNU6-548P →	+0.875	+4.127	<.001	<.001	3	2
SKCM	OR8B8 →	+0.018	+4.408	<.001	.005	3	2
SKCM	MIR133B →	+0.455	+4.408	<.001	.005	3	2
SKCM	RNU6-855P →	+0.151	+5.225	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 143 associations by consensus.

RWDD1 by ALG14 expression — UCEC

Explore this box plot interactively →