ALG14

Across TCGA pan-cancer cohorts, ALG14 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ALG14 data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher ALG14 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ALG14 expression acts as an unfavorable survival marker, although some lineages such as KIRC and COAD show a favorable association.

KICH, KIRC, and UVM are the cancer types where ALG14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Quartile	II,III,IV	0.457	1.000	<.001	98	view →
KIRC	OS	Median	All	0.706	0.544	<.001	76	view →
UVM	DFS	Quartile	III,IV	0.125	1.000	<.001	73	view →
LGG	DFS	Median	All	0.638	0.845	<.001	53	view →
SCLC	DFS	Quartile	III,IV	0.404	0.934	<.001	43	view →
KIRP	DFS	Tertile	All	0.841	0.973	.001	38	view →
HNSC	DFS	Median	IV	0.576	0.749	.003	34	view →
LIHC	OS	Tertile	All	0.709	0.869	.001	31	view →
ACC	DFS	Median	All	0.235	0.811	<.001	27	view →
COAD	OS	Median	All	0.740	0.482	<.001	23	view →
LUAD	DFS	Tertile	II,III,IV	0.607	0.781	.010	11	view →
BRCA	OS	Median	IV	0.757	0.368	.024	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ALG14–KICH (OS)

Open the KICH breakdown →