ALG10B

Across TCGA patient cohorts, ALG10B mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALG10B-associated genes across cancer lineages are p62 Lck ligand, S6_pS240_S244, and TAZ. Each is linked with ALG10B in more than 1 cancer types. Because this analysis shows association rather than direction, both ALG10B-to-partner and partner-to-ALG10B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ALG10B-low versus ALG10B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG10B→partner) and Y-score (partner→ALG10B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.431	+2.916	<.001	<.001	3	2
UCEC	S6_pS240_S244 →	+0.413	+2.183	.006	.033	3	2
UCEC	TAZ →	-0.111	-1.415	.036	.046	3	2
UCEC	14-3-3_beta →	-0.093	-3.143	.014	.018	3	1
UCEC	eIF4E →	+0.166	+2.169	.036	.003	3	1
UCEC	eIF4G →	+0.268	+3.169	.021	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

p62 Lck ligand by ALG10B expression — UCEC

Explore this box plot interactively →