ALG10B

Across TCGA pan-cancer cohorts, ALG10B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ALG10B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ALG10B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ALG10B is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, THCA, and BLCA are the cancer types where ALG10B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALG10B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.658	<.001	11	view →
THCA	All	All	−0.357	<.001	8	view →
BLCA	Female	All	+0.766	<.001	6	view →
CHOL	Male	All	+1.173	<.001	5	view →
KIRP	All	II,III,IV	+0.647	.008	5	view →
LIHC	All	All	+0.310	<.001	5	view →
LUSC	All	All	+0.354	<.001	4	view →
KICH	All	All	−0.600	<.001	3	view →
LUAD	All	All	+0.313	<.001	3	view →
BRCA	All	III,IV	+0.363	.031	2	view →
PRAD	All	All	+0.227	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ALG10B–HNSC

Open the HNSC breakdown →