ALG10B

Across TCGA pan-cancer cohorts, ALG10B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ALG10B data layer compared with 7 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher ALG10B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ALG10B expression acts as an unfavorable survival marker, although some lineages such as BRCA and SCLC show a favorable association.

BRCA, SCLC, and KIRC are the cancer types where ALG10B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	II,III,IV	0.962	0.920	.002	56	view →
SCLC	DFS	Quartile	II,III,IV	0.576	0.229	.006	52	view →
KIRC	DFS	Quartile	All	0.878	0.673	.003	46	view →
STAD	OS	Quartile	II,III,IV	0.525	0.794	.008	42	view →
UVM	DFS	Quartile	III,IV	0.232	0.832	.004	35	view →
OV	DFS	Tertile	III,IV	0.569	0.458	.008	28	view →
UCS	DFS	Median	IV	0.835	0.490	.031	22	view →
THCA	OS	Median	II,III,IV	0.839	0.979	.007	19	view →
LGG	OS	Median	All	0.757	0.897	.001	17	view →
LIHC	DFS	Median	All	0.484	0.600	.007	12	view →
ACC	DFS	Quartile	All	0.391	0.794	.003	11	view →
CESC	DFS	Quartile	III,IV	0.226	0.811	.004	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ALG10B–BRCA (DFS)

Open the BRCA breakdown →