ALG10B

Across TCGA cell cohorts, ALG10B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,717 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ALG10B-associated GO terms across cancer lineages are Cell cycle checkpoint signaling, Mitotic G2/M transition checkpoint, and Regulation of heterochromatin organization. Each is linked with ALG10B in more than 9 cancer types. Because this analysis shows association rather than direction, both ALG10B-to-partner and partner-to-ALG10B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell cycle checkpoint signaling grouped by ALG10B-low versus ALG10B-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALG10B→partner) and Y-score (partner→ALG10B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cell cycle checkpoint signaling →	+0.092	+0.974	.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Mitotic G2/M transition checkpoint →	+0.109	+1.120	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of heterochromatin organization →	+0.083	+0.930	.004	.001	3	10
BLOOD_Myeloma	DNA-templated DNA replication maintenance of fidelity →	+0.092	+0.931	.003	.003	3	10
BONE	Negative regulation of gene expression, epigenetic →	+0.078	+0.736	.001	.001	3	10
SOFT_TISSUE	Double-strand break repair via nonhomologous end joining →	+0.048	+0.738	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,717 associations by consensus.

Cell cycle checkpoint signaling by ALG10B expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →