ALDH8A1

Across TCGA patient cohorts, ALDH8A1 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,350 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ALDH8A1-associated proteins across cancer lineages are SH3BGRL2, AP2A1, and UPP1. Each is linked with ALDH8A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALDH8A1-to-partner and partner-to-ALDH8A1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ALDH8A1 versus SH3BGRL2 in GBM, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH8A1→partner) and Y-score (partner→ALDH8A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SH3BGRL2 →	+0.507	+0.786	<.001	<.001	3	3
GBM	AP2A1 →	+0.280	+0.616	.001	.001	3	3
HNSC	UPP1 →	-0.749	-0.854	<.001	.004	3	3
GBM	PACS1 →	+0.294	+0.624	<.001	<.001	3	3
GBM	USP16 →	-0.213	-0.512	<.001	.001	3	3
BRCA	RBM42 →	-0.148	-0.495	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,350 associations by consensus.

ALDH8A1 vs SH3BGRL2 — GBM

Explore this scatter interactively →