ALDH8A1

Across TCGA pan-cancer cohorts, ALDH8A1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ALDH8A1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ALDH8A1 RNA is repressed in tumor relative to normal tissue. In most cancer types ALDH8A1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and BLCA are the cancer types where ALDH8A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ALDH8A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−5.774	<.001	11	view →
THCA	Male	All	−0.242	<.001	10	view →
BLCA	All	III,IV	−0.400	.005	9	view →
LIHC	Female	All	−2.517	<.001	8	view →
HNSC	Male	IV	+0.364	<.001	8	view →
KIRC	Male	All	−1.085	<.001	7	view →
CHOL	All	II,III,IV	−5.400	<.001	5	view →
LUAD	All	All	−0.282	<.001	5	view →
UCEC	All	IV	−0.675	.032	2	view →
PRAD	All	All	−0.123	.006	2	view →
LUSC	All	II,III,IV	+0.445	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ALDH8A1–KICH

Open the KICH breakdown →