ALDH8A1

Across TCGA cell cohorts, ALDH8A1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ALDH8A1-associated genes across cancer lineages are ANKRD30BL, APOL5, and PSG6. Each is linked with ALDH8A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ALDH8A1-to-partner and partner-to-ALDH8A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD30BL grouped by ALDH8A1-low versus ALDH8A1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH8A1→partner) and Y-score (partner→ALDH8A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ANKRD30BL →	+0.630	+3.289	<.001	.009	3	2
BLOOD_Leukemia	APOL5 →	+0.010	+3.475	.007	.006	3	1
BLOOD_Leukemia	PSG6 →	+0.027	+3.450	<.001	.004	3	1
BLOOD_Leukemia	C14orf177 →	+0.050	+3.922	<.001	.002	3	1
BLOOD_Leukemia	LCE2A →	+0.035	+3.969	<.001	.009	3	1
BLOOD_Leukemia	OR6C75 →	+0.008	+4.569	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ANKRD30BL by ALDH8A1 expression — BLOOD_Leukemia

Explore this box plot interactively →