AKTIP

Across TCGA patient cohorts, AKTIP mutation is significantly associated with the RNA expression of many other genes, with 1,271 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKTIP-associated genes across cancer lineages are RN7SL248P, RNA5SP162, and MIR6765. Each is linked with AKTIP in more than 1 cancer types. Because this analysis shows association rather than direction, both AKTIP-to-partner and partner-to-AKTIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by AKTIP-low versus AKTIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKTIP→partner) and Y-score (partner→AKTIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.067	+3.400	<.001	.003	3	2
CESC	RNA5SP162 →	+0.771	+5.103	<.001	.008	3	2
BRCA	MIR6765 →	+0.490	+6.442	<.001	.001	3	1
BRCA	RN7SL722P →	+0.079	+7.471	<.001	.008	3	1
BRCA	SEPTIN14P17 →	+0.261	+5.575	<.001	.004	3	1
BRCA	SPATA31A3 →	+0.021	+5.347	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,271 associations by consensus.

RN7SL248P by AKTIP expression — UCEC

Explore this box plot interactively →