AKTIP

Across TCGA pan-cancer cohorts, AKTIP RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of AKTIP’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where AKTIP RNA is repressed in tumor relative to normal tissue. In most cancer types AKTIP is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, LUSC, and LUAD are the cancer types where AKTIP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKTIP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.591	<.001	8	view →
LUSC	Female	II,III,IV	−1.112	<.001	7	view →
LUAD	Female	III,IV	−0.586	<.001	6	view →
UCEC	All	All	−0.818	<.001	4	view →
HNSC	Male	All	−0.446	.001	4	view →
COAD	All	II,III,IV	−0.278	.009	4	view →
CHOL	All	All	+1.184	<.001	3	view →
KICH	All	III,IV	−0.668	.009	3	view →
LIHC	Male	All	+0.422	<.001	3	view →
READ	All	All	−0.516	.035	2	view →
KIRP	Female	II,III,IV	+0.488	.012	2	view →
PRAD	All	All	−0.396	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

AKTIP–THCA

Open the THCA breakdown →