AKT3

Across TCGA cell cohorts, AKT3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AKT3-associated genes across cancer lineages are RSPO2, PRR35, and DSCAM. Each is linked with AKT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKT3-to-partner and partner-to-AKT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RSPO2 grouped by AKT3-low versus AKT3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKT3→partner) and Y-score (partner→AKT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RSPO2 →	+0.148	+3.743	.002	.001	3	1
LARGE_INTESTINE	PRR35 →	+0.095	+3.887	<.001	.005	3	1
LARGE_INTESTINE	DSCAM →	+0.061	+4.000	.001	.004	3	1
LARGE_INTESTINE	TBC1D3 →	+0.063	+2.688	<.001	.008	3	1
LARGE_INTESTINE	AFF3 →	+0.494	+3.285	.004	.007	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

RSPO2 by AKT3 expression — LARGE_INTESTINE

Explore this box plot interactively →