AKT3

Across TCGA pan-cancer cohorts, AKT3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AKT3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AKT3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AKT3 is over-expressed in tumor, although a few such as BLCA and UCEC show the opposite, repressed pattern.

HNSC, BLCA, and UCEC are the cancer types where AKT3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKT3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.473	<.001	12	view →
BLCA	All	All	−1.342	.002	8	view →
UCEC	All	All	−3.426	<.001	6	view →
LUAD	Female	III,IV	−1.506	<.001	6	view →
KICH	All	All	−1.147	<.001	6	view →
BRCA	All	III,IV	−0.894	<.001	6	view →
COAD	All	All	−0.605	.002	5	view →
THCA	All	All	−0.323	.005	4	view →
CHOL	All	All	+2.001	<.001	3	view →
LUSC	Female	All	−1.331	<.001	3	view →
READ	Female	All	−2.150	.006	2	view →
LIHC	Female	All	+0.438	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

AKT3–HNSC

Open the HNSC breakdown →