Across TCGA patient cohorts, AKR7L RNA expression is significantly associated with the protein abundance of many other proteins, with 15,291 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible AKR7L-associated proteins across cancer lineages are AKR7A3, CASP4, and PPP1R18. Each is linked with AKR7L in more than 6 cancer types. Because this analysis shows association rather than direction, both AKR7L-to-partner and partner-to-AKR7L results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR7L→partner) and Y-score (partner→AKR7L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	AKR7A3 →	+1.655	+1.053	<.001	<.001	3	7
HNSC	CASP4 →	-0.625	-0.394	<.001	<.001	3	6
GBM	PPP1R18 →	-0.404	-0.549	<.001	<.001	3	5
BRCA	RPL7 →	-0.332	-0.975	<.001	<.001	3	5
GBM	IKZF1 →	-0.443	-0.351	<.001	<.001	3	5
GBM	MGAT1 →	-0.362	-0.385	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,291 associations by consensus.

Exploration

AKR7L survival (RNA) · tumor vs normal (RNA) · all AKR7L data types