Across TCGA pan-cancer cohorts, AKR7L RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of AKR7L’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where AKR7L RNA is repressed in tumor relative to normal tissue. In most cancer types AKR7L is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.
KICH, COAD, and THCA are the cancer types where AKR7L tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKR7L RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.