Across TCGA patient cohorts, AKR7L mutation is significantly associated with the RNA expression of many other genes, with 1,059 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR7L-associated genes across cancer lineages are NF1P4, SPATA31A3, and LARP1BP1. Each is linked with AKR7L in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR7L-to-partner and partner-to-AKR7L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR7L→partner) and Y-score (partner→AKR7L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	NF1P4 →	+0.032	+5.954	<.001	.002	3	2
SARC	SPATA31A3 →	+0.059	+6.152	<.001	.001	3	2
SARC	LARP1BP1 →	+0.682	+5.778	<.001	.003	3	2
SARC	LINC01162 →	+0.293	+5.005	.008	.009	3	2
UCEC	MIR6803 →	+0.124	+4.156	<.001	.004	3	2
BRCA	MIR548AP →	+0.322	+8.055	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,059 associations by consensus.

Exploration

AKR7L survival (RNA) · tumor vs normal (RNA) · all AKR7L data types