AKR1C8P

Across TCGA patient cohorts, AKR1C8P mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR1C8P-associated genes across cancer lineages are GAPDH, AMPK_pT172, and VEGFR2. Each is linked with AKR1C8P in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR1C8P-to-partner and partner-to-AKR1C8P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by AKR1C8P-low versus AKR1C8P-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1C8P→partner) and Y-score (partner→AKR1C8P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GAPDH →	+0.595	+3.000	.028	.034	3	2
SKCM	AMPK_pT172 →	+0.354	+2.584	.020	.011	3	1
SKCM	VEGFR2 →	+0.264	+3.169	.035	.018	3	1
UCEC	ERK2 →	+0.262	+3.000	.006	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.208	-3.169	.014	.018	3	1
UCEC	Ku80 →	+0.352	+3.472	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

GAPDH by AKR1C8P expression — SKCM

Explore this box plot interactively →