AKR1C8P

Across TCGA pan-cancer cohorts, AKR1C8P RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated AKR1C8P data layer compared with 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher AKR1C8P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated AKR1C8P expression acts as an unfavorable survival marker, although some lineages such as PAAD and LUSC show a favorable association.

HNSC, LUAD, and PAAD are the cancer types where AKR1C8P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	III,IV	0.272	0.578	.008	45	view →
LUAD	DFS	Median	II,III,IV	0.102	0.369	.003	38	view →
PAAD	DFS	Tertile	II,III,IV	0.609	0.360	<.001	34	view →
CHOL	OS	Tertile	III,IV	0.162	0.915	.010	29	view →
KIRP	DFS	Median	All	0.867	0.960	.001	24	view →
LUSC	OS	Median	All	0.802	0.720	.016	20	view →
STAD	DFS	Quartile	II,III,IV	0.481	0.652	.023	12	view →
SKCM	DFS	Quartile	III,IV	0.428	0.214	.019	10	view →
MESO	OS	Quartile	II,III,IV	0.345	0.740	.039	9	view →
READ	OS	Median	III,IV	0.689	0.270	.005	8	view →
THYM	DFS	Median	II,III,IV	0.843	0.609	.040	7	view →
KIRC	DFS	Quartile	IV	0.786	0.561	.031	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

AKR1C8P–HNSC (OS)

Open the HNSC breakdown →