AKR1C8P

Across TCGA pan-cancer cohorts, AKR1C8P RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AKR1C8P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where AKR1C8P RNA is repressed in tumor relative to normal tissue. In most cancer types AKR1C8P is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, HNSC, and BRCA are the cancer types where AKR1C8P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKR1C8P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.160	<.001	11	view →
HNSC	All	II,III,IV	+0.106	<.001	7	view →
BRCA	All	III,IV	−0.136	<.001	6	view →
COAD	All	All	+0.127	.003	6	view →
KIRC	All	All	+0.110	.002	5	view →
LUSC	All	All	+0.095	.023	4	view →
STAD	All	All	+0.086	.008	4	view →
CHOL	All	All	−1.575	<.001	3	view →
BLCA	Female	All	+0.180	.023	3	view →
KIRP	All	All	+0.125	.036	2	view →
LIHC	Male	All	+0.500	.021	1	view →
READ	All	All	+0.060	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

AKR1C8P–KICH

Open the KICH breakdown →