AKR1C4

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, AKR1C4 mutation is significantly associated with the RNA expression of many other genes, with 3,939 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR1C4-associated genes across cancer lineages are SNHG21, BRCC3P1, and RNU6-1153P. Each is linked with AKR1C4 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR1C4-to-partner and partner-to-AKR1C4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1C4→partner) and Y-score (partner→AKR1C4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMSNHG21 →+0.682+2.172<.001.00932
UCECBRCC3P1 →+0.383+3.717.005<.00132
UCECRNU6-1153P →+0.453+1.660.005.00932
SKCMRNU6-548P →+0.582+2.813.007.00132
SKCMITFG2-AS1 →+0.431+3.510<.001.00232
UCECHNRNPCP1 →+0.726+4.000<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,939 associations by consensus.

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