Across TCGA patient cohorts, AKR1C1 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,428 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AKR1C1-associated proteins across cancer lineages are AKR1C2, AKR1C3, and ALDH1A1. Each is linked with AKR1C1 in more than 9 cancer types. Because this analysis shows association rather than direction, both AKR1C1-to-partner and partner-to-AKR1C1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1C1→partner) and Y-score (partner→AKR1C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AKR1C2 →	+2.622	+2.057	<.001	<.001	3	10
LSCC	AKR1C3 →	+2.010	+3.862	<.001	<.001	3	8
GBM	ALDH1A1 →	+0.793	+0.772	<.001	<.001	3	6
LSCC	CES1 →	+1.719	+3.345	<.001	<.001	3	5
LSCC	PGD →	+0.754	+3.500	<.001	<.001	3	5
GBM	RFC4 →	-0.346	-0.698	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,428 associations by consensus.

Exploration

AKR1C1 survival (RNA) · tumor vs normal (RNA) · all AKR1C1 data types