Across TCGA patient cohorts, AKR1C1 mutation is significantly associated with the RNA expression of many other genes, with 1,185 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKR1C1-associated genes across cancer lineages are RNY4P27, ILKAP, and FAM138D. Each is linked with AKR1C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKR1C1-to-partner and partner-to-AKR1C1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1C1→partner) and Y-score (partner→AKR1C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNY4P27 →	+0.336	+5.229	<.001	.002	3	2
UCEC	ILKAP →	+0.447	+3.499	.001	.002	3	2
BLCA	FAM138D →	+0.046	+5.033	<.001	.003	3	2
UCEC	TAF15 →	+0.628	+3.617	<.001	.001	3	1
UCEC	COPS8P1 →	+0.096	+2.315	<.001	.008	3	1
UCEC	NFYC-AS1 →	+0.464	+2.595	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,185 associations by consensus.

Exploration

AKR1C1 survival (RNA) · tumor vs normal (RNA) · all AKR1C1 data types