Across TCGA cell cohorts, AKR1B15 mutation is significantly associated with the mutation status of many other genes, with 2,705 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AKR1B15-associated genes across cancer lineages are COL27A1, FSTL5, and SMC4. Each is linked with AKR1B15 in more than 3 cancer types. Because this analysis shows association rather than direction, both AKR1B15-to-partner and partner-to-AKR1B15 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKR1B15→partner) and Y-score (partner→AKR1B15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	COL27A1 →	+3.400	+4.784	<.001	<.001	1	4
OESOPHAGUS	FSTL5 →	+4.307	+3.672	.004	.004	1	3
BLOOD_Lymphoma	SMC4 →	+4.014	+4.969	.008	.008	1	3
BLOOD_Lymphoma	KNG1 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	SLCO5A1 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	CD109 →	+4.014	+4.969	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,705 associations by consensus.

Exploration

AKR1B15 survival (RNA) · tumor vs normal (RNA) · all AKR1B15 data types