AKIRIN1

Across TCGA patient cohorts, AKIRIN1 mutation is significantly associated with the RNA expression of many other genes, with 93 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKIRIN1-associated genes across cancer lineages are TXNL1P1, MIR892C, and MIR4778. Each is linked with AKIRIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKIRIN1-to-partner and partner-to-AKIRIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNL1P1 grouped by AKIRIN1-low versus AKIRIN1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKIRIN1→partner) and Y-score (partner→AKIRIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TXNL1P1 →	+0.064	+7.924	<.001	.008	3	2
BRCA	MIR892C →	+0.548	+9.057	<.001	.003	3	1
BRCA	MIR4778 →	+0.390	+8.471	<.001	.005	3	1
BLCA	SLC20A1P3 →	+0.049	+7.640	<.001	.009	3	1
UCEC	ZC3H12D →	+0.353	+3.210	.002	.009	3	1
UCEC	MIR4727 →	+0.358	+3.329	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

TXNL1P1 by AKIRIN1 expression — LUSC

Explore this box plot interactively →