AKIRIN1

Across TCGA pan-cancer cohorts, AKIRIN1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AKIRIN1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where AKIRIN1 RNA is repressed in tumor relative to normal tissue. In most cancer types AKIRIN1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and THCA are the cancer types where AKIRIN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKIRIN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.731	<.001	11	view →
KIRC	Male	II,III,IV	−1.244	<.001	11	view →
THCA	Male	III,IV	−0.915	<.001	10	view →
HNSC	All	III,IV	+0.728	<.001	9	view →
KIRP	Male	All	−1.116	<.001	6	view →
BLCA	All	IV	−0.612	.004	4	view →
CHOL	All	All	+1.022	.006	2	view →
ESCA	Female	All	+0.819	.003	2	view →
STAD	All	II,III,IV	+0.415	.018	2	view →
PRAD	All	All	−0.245	.039	2	view →
LIHC	All	III,IV	+0.436	.049	1	view →
COAD	Male	III,IV	−0.376	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

AKIRIN1–KICH

Open the KICH breakdown →