AKIRIN1

Across TCGA pan-cancer cohorts, AKIRIN1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated AKIRIN1 data layer compared with 1 for mutation status.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher AKIRIN1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated AKIRIN1 expression acts as an unfavorable survival marker, although some lineages such as UCS and PAAD show a favorable association.

LIHC, ACC, and LGG are the cancer types where AKIRIN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.670	0.831	<.001	74	view →
ACC	DFS	Tertile	All	0.196	0.758	<.001	73	view →
LGG	DFS	Median	All	0.645	0.835	<.001	53	view →
CESC	DFS	Tertile	III,IV	0.365	0.815	.010	42	view →
UCS	DFS	Tertile	IV	0.936	0.488	.024	26	view →
PAAD	OS	Quartile	All	0.638	0.309	.003	20	view →
SKCM	DFS	Quartile	II,III,IV	0.437	0.189	.004	14	view →
KICH	OS	Quartile	II,III,IV	0.622	1.000	.012	12	view →
UCEC	DFS	Quartile	All	0.655	0.831	.002	12	view →
HNSC	OS	Median	III,IV	0.256	0.402	.012	12	view →
SCLC	DFS	Tertile	All	0.553	0.935	.010	11	view →
KIRC	OS	Median	All	0.691	0.574	.018	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

AKIRIN1–LIHC (OS)

Open the LIHC breakdown →