AKIRIN1

Across TCGA patient cohorts, AKIRIN1 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKIRIN1-associated genes across cancer lineages are CD4+ Tcm, CD8+ T-cells, and Th1 cells. Each is linked with AKIRIN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKIRIN1-to-partner and partner-to-AKIRIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD4+ Tcm grouped by AKIRIN1-low versus AKIRIN1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKIRIN1→partner) and Y-score (partner→AKIRIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CD4+ Tcm →	+0.014	+6.593	<.001	.020	3	1
UCEC	CD8+ T-cells →	+0.015	+2.622	.019	.022	3	1
UCEC	Th1 cells →	+0.119	+3.169	.020	.020	3	1
UCEC	CD8+ naive T-cells →	+0.057	+3.016	<.001	.019	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CD4+ Tcm by AKIRIN1 expression — LUSC

Explore this box plot interactively →