AKAP8L

Across TCGA patient cohorts, AKAP8L mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAP8L-associated genes across cancer lineages are FOXO3a_pS318_S321, mTOR_pS2448, and TIGAR. Each is linked with AKAP8L in more than 1 cancer types. Because this analysis shows association rather than direction, both AKAP8L-to-partner and partner-to-AKAP8L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by AKAP8L-low versus AKAP8L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP8L→partner) and Y-score (partner→AKAP8L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.139	-3.449	.013	.005	3	2
UCEC	mTOR_pS2448 →	-0.167	-2.000	.012	.032	3	1
UCEC	TIGAR →	+0.141	+2.727	.040	.003	3	1
UCEC	ATM →	-0.720	-3.459	<.001	.005	3	1
UCEC	c-Met_pY1235 →	+0.072	+2.179	.031	.034	3	1
UCEC	ACC1 →	+0.458	+2.700	.005	.006	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FOXO3a_pS318_S321 by AKAP8L expression — UCEC

Explore this box plot interactively →