AKAP8L

Across TCGA pan-cancer cohorts, AKAP8L RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated AKAP8L data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher AKAP8L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated AKAP8L expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

KIRC, KICH, and LIHC are the cancer types where AKAP8L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.544	0.693	<.001	134	view →
KICH	OS	Median	III,IV	0.347	0.942	.001	80	view →
LIHC	DFS	Median	All	0.457	0.625	<.001	73	view →
COAD	DFS	Tertile	All	0.597	0.776	<.001	70	view →
ACC	DFS	Median	All	0.275	0.632	<.001	69	view →
HNSC	DFS	Median	IV	0.377	0.252	.006	52	view →
PRAD	DFS	Tertile	All	0.690	0.923	<.001	34	view →
PAAD	DFS	Tertile	All	0.452	0.162	<.001	30	view →
MESO	OS	Median	All	0.472	0.605	.010	27	view →
SKCM	DFS	Quartile	III,IV	0.527	0.881	.002	25	view →
UCEC	DFS	Median	All	0.776	0.892	<.001	22	view →
ESCA	DFS	Median	II,III,IV	1.000	0.388	.010	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

AKAP8L–KIRC (DFS)

Open the KIRC breakdown →