AKAP8L

Across TCGA pan-cancer cohorts, AKAP8L RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AKAP8L’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where AKAP8L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types AKAP8L is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where AKAP8L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKAP8L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.777	<.001	11	view →
COAD	All	IV	+0.968	<.001	10	view →
LIHC	Female	II,III,IV	+1.652	<.001	9	view →
STAD	All	II,III,IV	+0.607	.003	6	view →
LUSC	Male	All	+0.322	.001	5	view →
READ	All	All	+0.612	.008	4	view →
BRCA	All	All	+0.206	.011	4	view →
CHOL	All	All	+2.308	<.001	3	view →
KIRC	Female	All	+0.293	.017	3	view →
KIRP	All	IV	+0.839	.034	2	view →
ESCA	All	All	+0.633	.003	2	view →
KICH	Female	All	−0.585	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

AKAP8L–HNSC

Open the HNSC breakdown →