AKAP8L

Across TCGA cell cohorts, AKAP8L RNA expression is significantly associated with the go_rna of many other GO terms, with 4,491 significant associations in total. BONE shows the largest number of these associations.

The most reproducible AKAP8L-associated GO terms across cancer lineages are Protein-DNA complex organization, Negative regulation of transcription elongation by RNA polymerase II, and Regulation of proteasomal ubiquitin-dependent protein catabolic process. Each is linked with AKAP8L in more than 15 cancer types. Because this analysis shows association rather than direction, both AKAP8L-to-partner and partner-to-AKAP8L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein-DNA complex organization grouped by AKAP8L-low versus AKAP8L-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP8L→partner) and Y-score (partner→AKAP8L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Protein-DNA complex organization →	+0.063	+0.761	<.001	.002	3	16
UPPER_AERODIGESTIVE_TRACT	Negative regulation of transcription elongation by RNA polymerase II →	+0.126	+0.540	.001	.003	3	16
STOMACH	Regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.065	+0.511	<.001	.001	3	16
OVARY	Regulation of myoblast fusion →	+0.097	+0.672	.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Spliceosomal complex assembly →	+0.096	+0.814	.001	<.001	3	15
STOMACH	Heterochromatin formation →	+0.079	+0.600	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,491 associations by consensus.

Protein-DNA complex organization by AKAP8L expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →