AKAP8L

Across TCGA cell cohorts, AKAP8L mutation is significantly associated with the RNA expression of many other genes, with 90 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AKAP8L-associated genes across cancer lineages are ASPG, OR10Q1, and CLDN34. Each is linked with AKAP8L in more than 1 cancer types. Because this analysis shows association rather than direction, both AKAP8L-to-partner and partner-to-AKAP8L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASPG grouped by AKAP8L-low versus AKAP8L-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP8L→partner) and Y-score (partner→AKAP8L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASPG →	+0.208	+3.803	.007	.004	3	1
BLOOD_Leukemia	OR10Q1 →	+0.010	+3.969	.002	.009	3	1
BLOOD_Leukemia	CLDN34 →	+0.045	+4.569	<.001	.003	3	1
BLOOD_Leukemia	SERPINA2 →	+0.010	+3.969	.006	.009	3	1
BLOOD_Leukemia	ADAM7 →	+0.019	+3.922	<.001	.002	3	1
BLOOD_Leukemia	DAZL →	+0.095	+4.007	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

ASPG by AKAP8L expression — BLOOD_Leukemia

Explore this box plot interactively →