AKAP7

Across TCGA cell cohorts, AKAP7 mutation is significantly associated with the RNA expression of many other genes, with 323 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AKAP7-associated genes across cancer lineages are C20orf85, IL22, and CST2. Each is linked with AKAP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both AKAP7-to-partner and partner-to-AKAP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by AKAP7-low versus AKAP7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP7→partner) and Y-score (partner→AKAP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf85 →	+0.036	+4.969	<.001	.003	3	1
BLOOD_Leukemia	IL22 →	+0.037	+5.569	<.001	.001	3	1
BLOOD_Leukemia	CST2 →	+0.713	+4.152	<.001	.009	3	1
BLOOD_Leukemia	LRRTM3 →	+0.004	+4.539	<.001	.007	3	1
BLOOD_Leukemia	CBLN4 →	+0.004	+4.539	<.001	.007	3	1
LARGE_INTESTINE	RNF125 →	+0.965	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 323 associations by consensus.

C20orf85 by AKAP7 expression — BLOOD_Leukemia

Explore this box plot interactively →