AKAP7

Across TCGA pan-cancer cohorts, AKAP7 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of AKAP7’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where AKAP7 RNA is repressed in tumor relative to normal tissue. In most cancer types AKAP7 is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, LUAD, and KICH are the cancer types where AKAP7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AKAP7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−1.874	<.001	11	view →
LUAD	Female	III,IV	−1.342	<.001	11	view →
KICH	All	III,IV	−1.101	<.001	11	view →
KIRP	All	All	+0.530	<.001	9	view →
BLCA	Male	III,IV	−1.107	.002	8	view →
THCA	All	II,III,IV	−0.644	<.001	8	view →
LUSC	Male	III,IV	−1.597	<.001	6	view →
BRCA	All	III,IV	−1.145	<.001	6	view →
KIRC	All	All	+0.247	.001	4	view →
CHOL	Female	All	+3.803	.001	2	view →
READ	All	All	−1.567	<.001	2	view →
PRAD	All	All	−0.409	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

AKAP7–COAD

Open the COAD breakdown →