AKAP11

Across TCGA patient cohorts, AKAP11 mutation is significantly associated with the RNA expression of many other genes, with 4,467 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AKAP11-associated genes across cancer lineages are DOT1L, MIR6769B, and SENP3-EIF4A1. Each is linked with AKAP11 in more than 3 cancer types. Because this analysis shows association rather than direction, both AKAP11-to-partner and partner-to-AKAP11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DOT1L grouped by AKAP11-low versus AKAP11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AKAP11→partner) and Y-score (partner→AKAP11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DOT1L →	+0.472	+2.158	<.001	<.001	3	4
BLCA	MIR6769B →	+0.168	+3.870	<.001	.009	3	3
UCEC	SENP3-EIF4A1 →	+0.081	+1.871	<.001	<.001	3	3
UCEC	MPV17L →	-0.555	-1.680	<.001	<.001	3	3
UCEC	FBXW5 →	+0.291	+2.212	.007	<.001	3	3
UCEC	LMNB2 →	+0.476	+1.514	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,467 associations by consensus.

DOT1L by AKAP11 expression — UCEC

Explore this box plot interactively →