AKAP11

Across TCGA pan-cancer cohorts, AKAP11 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated AKAP11 data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher AKAP11 RNA is associated with better overall survival. In most high-consensus cancer types, elevated AKAP11 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

KIRC, CESC, and OV are the cancer types where AKAP11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.719	0.544	<.001	83	view →
CESC	DFS	Median	All	0.415	0.692	<.001	76	view →
OV	OS	Tertile	III,IV	0.252	0.360	.004	38	view →
LGG	DFS	Median	All	0.800	0.669	<.001	36	view →
BLCA	DFS	Tertile	All	0.168	0.572	.001	26	view →
PAAD	OS	Quartile	All	0.715	0.441	.006	18	view →
UVM	OS	Tertile	III,IV	0.318	1.000	.016	16	view →
ACC	DFS	Median	All	0.546	0.763	.010	16	view →
SCLC	OS	Median	II,III,IV	0.800	0.574	.006	14	view →
DLBC	DFS	Median	All	0.626	0.917	.010	10	view →
MESO	DFS	Quartile	All	0.335	0.760	.026	9	view →
HNSC	DFS	Quartile	IV	0.565	0.317	.021	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

AKAP11–KIRC (OS)

Open the KIRC breakdown →