AHSG

Across TCGA cell cohorts, AHSG mutation is significantly associated with the mutation status of many other genes, with 2,888 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AHSG-associated genes across cancer lineages are NCK2, CARD10, and PRX. Each is linked with AHSG in more than 2 cancer types. Because this analysis shows association rather than direction, both AHSG-to-partner and partner-to-AHSG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCK2 grouped by AHSG-low versus AHSG-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AHSG→partner) and Y-score (partner→AHSG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NCK2 →	+2.630	+3.047	.005	.005	1	3
BLOOD_Leukemia	CARD10 →	+3.145	+3.932	.004	.004	1	3
LARGE_INTESTINE	PRX →	+3.799	+5.217	<.001	<.001	1	3
BLOOD_Leukemia	TEX14 →	+2.823	+3.665	.008	.008	1	3
LARGE_INTESTINE	ITGB4 →	+1.799	+3.769	.002	.002	1	3
LARGE_INTESTINE	ECPAS →	+2.077	+3.129	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,888 associations by consensus.

NCK2 by AHSG expression — LARGE_INTESTINE

Explore this box plot interactively →