AGTR2

Across TCGA patient cohorts, AGTR2 mutation is significantly associated with the RNA expression of many other genes, with 2,965 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AGTR2-associated genes across cancer lineages are NADK, RNU6-457P, and KRTAP1-3. Each is linked with AGTR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AGTR2-to-partner and partner-to-AGTR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NADK grouped by AGTR2-low versus AGTR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGTR2→partner) and Y-score (partner→AGTR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NADK →	+0.329	+1.592	.004	.005	3	3
GBM	RNU6-457P →	+0.402	+4.969	.001	.009	3	2
GBM	KRTAP1-3 →	+0.075	+4.969	<.001	.009	3	2
LUAD	RNU6-911P →	+0.707	+3.914	.001	.004	3	2
COAD	TRAJ47 →	+1.025	+4.221	<.001	.003	3	2
ESCA	OR4A21P →	+0.070	+4.681	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,965 associations by consensus.

NADK by AGTR2 expression — UCEC

Explore this box plot interactively →