AGTR2

Across TCGA pan-cancer cohorts, AGTR2 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated AGTR2 data layer compared with 9 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher AGTR2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated AGTR2 expression acts as an unfavorable survival marker, although some lineages such as BRCA and THCA show a favorable association.

KIRP, HNSC, and BRCA are the cancer types where AGTR2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.720	0.889	<.001	56	view →
HNSC	OS	Quartile	All	0.272	0.442	.008	47	view →
BRCA	OS	Tertile	III,IV	0.720	0.397	.007	36	view →
STAD	OS	Tertile	IV	0.152	0.487	.013	33	view →
UVM	OS	Tertile	All	0.220	0.917	<.001	27	view →
THCA	DFS	Tertile	All	0.977	0.879	.005	21	view →
LUSC	DFS	Median	All	0.686	0.804	.001	20	view →
READ	DFS	Tertile	III,IV	0.678	0.211	.009	18	view →
SKCM	DFS	Tertile	III,IV	0.270	0.516	.008	18	view →
LIHC	OS	Tertile	All	0.683	0.810	.028	15	view →
UCS	DFS	Tertile	III,IV	0.456	0.102	.030	14	view →
BLCA	DFS	Quartile	All	0.537	0.653	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

AGTR2–KIRP (DFS)

Open the KIRP breakdown →