AGTR1

Across TCGA cell cohorts, AGTR1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AGTR1-associated genes across cancer lineages are R3HDML, OR6C70, and OR14K1. Each is linked with AGTR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGTR1-to-partner and partner-to-AGTR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R3HDML grouped by AGTR1-low versus AGTR1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGTR1→partner) and Y-score (partner→AGTR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	R3HDML →	+0.146	+4.215	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR6C70 →	+0.292	+4.681	<.001	.003	3	1
LARGE_INTESTINE	OR14K1 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.055	+4.257	<.001	<.001	3	1
LARGE_INTESTINE	C16orf96 →	+0.519	+3.520	.003	.005	3	1
LARGE_INTESTINE	OR2W3 →	+1.149	+3.355	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

R3HDML by AGTR1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →