AGTR1

Across TCGA pan-cancer cohorts, AGTR1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of AGTR1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where AGTR1 RNA is repressed in tumor relative to normal tissue. In most cancer types AGTR1 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and KIRP are the cancer types where AGTR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AGTR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−3.562	<.001	11	view →
THCA	Male	IV	−2.913	<.001	11	view →
KIRP	Female	II,III,IV	−2.856	<.001	11	view →
KICH	Male	II,III,IV	−2.675	<.001	11	view →
COAD	Male	II,III,IV	−1.859	<.001	11	view →
LUSC	Female	II,III,IV	−2.801	<.001	9	view →
LUAD	Female	III,IV	−2.780	<.001	9	view →
STAD	All	All	−1.463	<.001	7	view →
KIRC	All	III,IV	−0.919	<.001	7	view →
UCEC	All	III,IV	−1.977	<.001	6	view →
BRCA	Female	All	−1.481	<.001	6	view →
READ	All	All	−2.606	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

AGTR1–BLCA

Open the BLCA breakdown →