AGAP5

Across TCGA cell cohorts, AGAP5 mutation is significantly associated with the RNA expression of many other genes, with 96 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AGAP5-associated genes across cancer lineages are FREM3, GAL3ST2, and FBXW10. Each is linked with AGAP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both AGAP5-to-partner and partner-to-AGAP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FREM3 grouped by AGAP5-low versus AGAP5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AGAP5→partner) and Y-score (partner→AGAP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FREM3 →	+0.198	+4.027	<.001	.004	3	2
BLOOD_Leukemia	GAL3ST2 →	+0.165	+3.605	<.001	.001	3	2
BLOOD_Leukemia	FBXW10 →	+0.027	+2.823	.008	.003	3	2
BLOOD_Leukemia	KHDC3L →	+0.101	+2.437	.002	.005	3	2
LARGE_INTESTINE	NEXMIF →	+0.210	+2.933	<.001	.003	3	2
LUNG_NSCLC_LUAD	PRSS55 →	+0.030	+4.662	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

FREM3 by AGAP5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →