Across TCGA patient cohorts, AFG3L1P mutation is significantly associated with the RNA expression of many other genes, with 365 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFG3L1P-associated genes across cancer lineages are H2AB2, RNA5SP481, and CWC25. Each is linked with AFG3L1P in more than 1 cancer types. Because this analysis shows association rather than direction, both AFG3L1P-to-partner and partner-to-AFG3L1P results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFG3L1P→partner) and Y-score (partner→AFG3L1P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	H2AB2 →	+0.083	+8.057	<.001	.005	3	1
BRCA	RNA5SP481 →	+0.331	+5.441	<.001	.005	3	1
UCEC	CWC25 →	+0.487	+2.638	.002	.005	3	1
UCEC	TAF9 →	+0.642	+3.343	<.001	.005	3	1
UCEC	TMEM269 →	+0.204	+3.324	.001	.007	3	1
UCEC	RNA5SP411 →	+0.886	+2.201	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 365 associations by consensus.

Exploration

AFG3L1P survival (RNA) · tumor vs normal (RNA) · all AFG3L1P data types