AFAP1L1

Across TCGA patient cohorts, AFAP1L1 mutation is significantly associated with the RNA expression of many other genes, with 4,609 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AFAP1L1-associated genes across cancer lineages are OR2G3, RNU6-522P, and HMGB1P23. Each is linked with AFAP1L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AFAP1L1-to-partner and partner-to-AFAP1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2G3 grouped by AFAP1L1-low versus AFAP1L1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AFAP1L1→partner) and Y-score (partner→AFAP1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR2G3 →	+0.041	+3.748	<.001	.002	3	3
READ	RNU6-522P →	+0.456	+4.096	<.001	.006	3	3
CESC	HMGB1P23 →	+0.182	+4.234	<.001	.003	3	3
LUSC	TRAJ1 →	+0.939	+3.677	.001	.005	3	3
UCEC	RNU6-308P →	+0.127	+2.220	.002	.004	3	3
BRCA	LCEP1 →	+0.134	+4.683	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,609 associations by consensus.

OR2G3 by AFAP1L1 expression — SKCM

Explore this box plot interactively →