ADRB1

Across TCGA cell cohorts, ADRB1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADRB1-associated genes across cancer lineages are LEUTX, TEX28, and IZUMO1R. Each is linked with ADRB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADRB1-to-partner and partner-to-ADRB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LEUTX grouped by ADRB1-low versus ADRB1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRB1→partner) and Y-score (partner→ADRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LEUTX →	+0.226	+5.321	<.001	.005	3	1
LUNG_NSCLC_LUAD	TEX28 →	+0.006	+5.228	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	IZUMO1R →	+0.053	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	FABP9 →	+0.060	+5.357	<.001	.003	3	1
LARGE_INTESTINE	OR2J1 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	MAGEB1 →	+0.230	+3.878	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

LEUTX by ADRB1 expression — CNS

Explore this box plot interactively →